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KMID : 1059520110550020240
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Journal of the Korean Chemical Society
2011 Volume.55 No. 2 p.240 ~ p.242
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Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues
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Keetha, Laxminarayana
Palle, Sadanandam
Ramanatham, Vinodkumar
Khagga, Mukkanti
Chinnapillai, Rajendiran
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Abstract
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A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.
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KEYWORD
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5-haloindoles, copper (I) chloride, N-methyl-2-pyrrolidone, halogen-halogen exchange
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